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Akkermansia Muciniphila Probiotic Granules * Live Long * Weight Control Dogadan Bizim (5)

£14.995£29.99Clearance
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Filippou CD, Tsioufis CP, Thomopoulos CG, Mihas CC, Dimitriadis KS, Sotiropoulou LI, Chrysochoou CA, Nihoyannopoulos PI, Tousoulis DM. Dietary approaches to stop hypertension (DASH) diet and blood pressure reduction in adults with and without hypertension: a systematic review and meta-analysis of randomized controlled trials. Adv Nutr. 2020;11:1150–60. Ding RX, Goh WR, Wu RN, Yue XQ, Luo X, Khine WWT, Wu JR, Lee YK. Revisit gut microbiota and its impact on human health and disease. J Food Drug Anal. 2019;27:623–31.

Li L, Bhatia M, Moore PK. Hydrogen sulphide–a novel mediator of inflammation? Curr Opin Pharmacol. 2006;6:125–9. Sun S, Lulla A, Sioda M, Winglee K, Wu MC, Jacobs DR Jr, Shikany JM, Lloyd-Jones DM, Launer LJ, Fodor AA, Meyer KA. Gut microbiota composition and blood pressure. Hypertension. 2019;73:998–1006. Gelis L, Jovancevic N, Veitinger S, Mandal B, Arndt HD, Neuhaus EM, Hatt H. Functional characterization of the odorant receptor 51E2 in human melanocytes. J Biol Chem. 2016;291:17772–86.Lau WL, Kalantar-Zadeh K, Vaziri ND. The gut as a source of inflammation in chronic kidney disease. Nephron. 2015;130:92–8. Ghaffari S, Abbasi A, Somi MH, Moaddab SY, Nikniaz L, Kafil HS, Leylabadlo HE. Akkermansia muciniphila: from its critical role in human health to strategies for promoting its abundance in human gut microbiome. Crit Rev Food Sci Nutr. 2022;1–21. Fish oil is controversial right now, with some scientists claiming that the benefits of it have been overstated. In one study comparing the effects of fish and fish oil, researchers found that levels of DHA (a fatty acid) in one group of people eating whole salmon were nine times higher than in a group that took fish oil (Source: NCBI). However, if you don’t like fish, or like the convenience of capsules, other research has shown that if you take them with a high-fat meal, you can increase the absorption of fatty acids to a point where they could be as beneficial as whole fish. Jabs S, Biton A, Becavin C, Nahori MA, Ghozlane A, Pagliuso A, Spano G, Guerineau V, Touboul D, Giai Gianetto Q, et al. Impact of the gut microbiota on the m(6)A epitranscriptome of mouse cecum and liver. Nat Commun. 2020;11:1344. Pellegrino A, Coppola G, Santopaolo F, et al. Role of Akkermansia in Human Diseases: From Causation to Therapeutic Properties. Nutrients. 2023 Apr 8;15(8):1815.

Liu X, Zhao F, Liu H, Xie Y, Zhao D, Li C. Transcriptomics and metabolomics reveal the adaption of Akkermansia muciniphila to high mucin by regulating energy homeostasis. Sci Rep. 2021;11:9073. Raftar SKA, Ashrafian F, Abdollahiyan S, Yadegar A, Moradi HR, Masoumi M, Vaziri F, Moshiri A, Siadat SD, Zali MR. The anti-inflammatory effects of Akkermansia muciniphila and its derivates in HFD/CCL4-induced murine model of liver injury. Sci Rep. 2022;12:2453. Rodríguez-Daza MC, de Vos WM. Polyphenols as Drivers of a Homeostatic Gut Microecology and Immuno-Metabolic Traits of Akkermansia muciniphila : From Mouse to Man. Int J Mol Sci. 2022 Dec 20;24(1):45. de la Cuesta-Zuluaga J, Mueller NT, Corrales-Agudelo V, Velasquez-Mejia EP, Carmona JA, Abad JM, Escobar JS. Metformin Is associated with higher relative abundance of mucin-degrading Akkermansia muciniphila and several short-chain fatty acid-producing microbiota in the gut. Diabetes Care. 2017;40:54–62.

De Pergola G, D’Alessandro A. Influence of mediterranean diet on blood pressure. Nutrients. 2018;10:1700. The ‘muciniphila’ part comes from Akkermansia’s love of mucus. That’s right, it loves to eat the slimy layer of mucus that coats our intestinal walls. It keeps us healthy at the same time, so that’s a good thing.

One of the critical features of A. muciniphila is that it is very "slimy" because it is covered in molecules known as exopolysaccharides. These slimy compounds prevent white blood cells from breaking down a beneficial protein known as Amuc_1100, found in the cell membrane surrounding A. muciniphila . It turns out that this protein is the secret to the bacteria's beneficial effects. You can encourage it to grow by raising your intake of polyphenol-rich foods, fish oil and prebiotics Le Poul E, Loison C, Struyf S, Springael JY, Lannoy V, Decobecq ME, Brezillon S, Dupriez V, Vassart G, Van Damme J, et al. Functional characterization of human receptors for short chain fatty acids and their role in polymorphonuclear cell activation. J Biol Chem. 2003;278:25481–9.

How Can I Boost Akkermansia Levels in My Gut?

Research on the intestinal microbiome is uncovering potential new probiotic species that could revolutionize medicine. The gut microbiome is a complex and diverse system composed of genetic material from trillions of microorganisms (microbiota). Without question, the microbiome is a huge contributor to our health and wellness. So in addition to polyphenols and fish oil, make sure you add prebiotic foods to your daily menu. Many of them also contain polyphenols, so your Akkermansia can get a double hit of goodness. For instance: Liu S, Rezende RM, Moreira TG, Tankou SK, Cox LM, Wu M, Song A, Dhang FH, Wei Z, Costamagna G, Weiner HL. Oral administration of miR-30d from feces of MS patients suppresses MS-like symptoms in mice by expanding Akkermansia muciniphila. Cell Host Microbe. 2019;26(779–794):e778.

Ouwerkerk JP, Aalvink S, Belzer C, de Vos WM. Akkermansia glycaniphila sp. nov., an anaerobic mucin-degrading bacterium isolated from reticulated python faeces. Int J Syst Evol Microbiol. 2016;66:4614–20. Caputo A, Dubourg G, Croce O, Gupta S, Robert C, Papazian L, Rolain JM, Raoult D. Whole-genome assembly of Akkermansia muciniphila sequenced directly from human stool. Biol Direct. 2015;10:5. Obach RS. Pharmacologically active drug metabolites: impact on drug discovery and pharmacotherapy. Pharmacol Rev. 2013;65:578–640.The amount of polyphenols in foods depends a lot on the soil it was grown in, how ripe it is, and how it was farmed, transported and prepared, so the following list is just a guide. Top 20 high-polyphenol foods (per serving) Tzima N, Pitsavos C, Panagiotakos DB, Skoumas J, Zampelas A, Chrysohoou C, Stefanadis C. Mediterranean diet and insulin sensitivity, lipid profile and blood pressure levels, in overweight and obese people; the Attica study. Lipids Health Dis. 2007;6:22.

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