AriZona x Marvel Super LXR Hero Hydration - Acai Blueberry - 16oz (Pack of 12) – Low Sugar Sports Drink, Perfect for Athletes, Vitamins and Natural Flavors - Thirst Quencher

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Joseph, S. B. et al. Synthetic LXR ligand inhibits the development of atherosclerosis in mice. Proc. Natl Acad. Sci. USA 99, 7604–7609 (2002). Unleash the beast and hydrate your way to ultimate power with Super LXR Hero Hydration: Citrus Lemon Lime flavour! Verschuren, L., de Vries-van der Weij, J., Zadelaar, S., Kleemann, R. & Kooistra, T. LXR agonist suppresses atherosclerotic lesion growth and promotes lesion regression in apoE*3Leiden mice: time course and mechanisms. J. Lipid Res. 50, 301–311 (2009). Tamura, K. et al. LXRalpha functions as a cAMP-responsive transcriptional regulator of gene expression. Proc. Natl Acad. Sci. USA 97, 8513–8518 (2000). Zhang, Y., Repa, J. J., Gauthier, K. & Mangelsdorf, D. J. Regulation of lipoprotein lipase by the oxysterol receptors, LXRalpha and LXRbeta. J. Biol. Chem. 276, 43018–43024 (2001).

Horlein, A. J. et al. Ligand-independent repression by the thyroid hormone receptor mediated by a nuclear receptor co-repressor. Nature 377, 397–404 (1995). US National Library of Medicine. ClinicalTrials.gov https://clinicaltrials.gov/ct2/show/NCT01651273 (2013). Yahagi, N. et al. A crucial role of sterol regulatory element-binding protein-1 in the regulation of lipogenic gene expression by polyunsaturated fatty acids. J. Biol. Chem. 274, 35840–35844 (1999). Hannah, V. C., Ou, J., Luong, A., Goldstein, J. L. & Brown, M. S. Unsaturated fatty acids down-regulate srebp isoforms 1a and 1c by two mechanisms in HEK-293 cells. J. Biol. Chem. 276, 4365–4372 (2001). Chen, K. F. et al. Activation of phosphatidylinositol 3-kinase/Akt signaling pathway mediates acquired resistance to sorafenib in hepatocellular carcinoma cells. J. Pharmacol. Exp. Ther. 337, 155–161 (2011).Lands, W. E. Metabolism of glycerolipids. 2. The enzymatic acylation of lysolecithin. J. Biol. Chem. 235, 2233–2237 (1960). Hong, C. et al. The LXR-Idol axis differentially regulates plasma LDL levels in primates and mice. Cell Metab. 20, 910–918 (2014). Chu, K., Miyazaki, M., Man, W. C. & Ntambi, J. M. Stearoyl-coenzyme A desaturase 1 deficiency protects against hypertriglyceridemia and increases plasma high-density lipoprotein cholesterol induced by liver X receptor activation. Mol. Cell. Biol. 26, 6786–6798 (2006).

Turn your reserves into usable energy! Once you’ve tried it, it’s gonna be a case of “LXR forever!” Doench, J. G. et al. Optimized sgRNA design to maximize activity and minimize off-target effects of CRISPR–Cas9. Nat. Biotechnol. 34, 184–191 (2016). Each of these flavors will be linked to a beloved Marvel Super Hero. Since heroes come in all shapes and sizes, the SUPER LXR™ flavorverse will only continue to expand with innovative offerings and more of your favorite Marvel Super Heroes. Moore, K. J., Sheedy, F. J. & Fisher, E. A. Macrophages in atherosclerosis: a dynamic balance. Nat. Rev. Immunol. 13, 709–721 (2013). Stachel, S. J. et al. Identification and in vivo evaluation of liver X receptor beta-selective agonists for the potential treatment of Alzheimer’s disease. J. Med. Chem. 59, 3489–3498 (2016).Rosmorduc, O. & Fartoux, L. HCC and NASH: how strong is the clinical demonstration? Clin. Res. Hepatol. Gastroenterol. 36, 202–208 (2012). Chasman, D. I. et al. Genetic determinants of statin-induced low-density lipoprotein cholesterol reduction: the Justification for the Use of Statins in Prevention: an Intervention Trial Evaluating Rosuvastatin (JUPITER) trial. Circ. Cardiovasc. Genet. 5, 257–264 (2012). Yau, T., Chan, P., Epstein, R. & Poon, R. T. Evolution of systemic therapy of advanced hepatocellular carcinoma. World J. Gastroenterol. 14, 6437–6441 (2008). Imagine sipping on the zesty and electrifying flavours of Citrus Lemon Lime as you channel the strength of Iron Man, the agility of Spider-Man, or the wisdom of Captain America. Whether you're embarking on an epic adventure or simply need a heroic hydration boost, Arizona x Marvel Super LXR Hero Hydration Citrus Lemon Lime promises a flavourful journey that's as thrilling as a Marvel comic book. So, grab your favourite superhero gear, take a sip, and let the heroic flavours invigorate your spirit, making you feel like you have the strength of Marvel's greatest characters with every refreshing gulp!