Joined in 2023 
82 
63 About this deal
Jean Luc Ishimwe, Xiang Li, Amin Danesh, Michael J Bolish, Abir K.M.S. Mahmud, Cacey S Bester, Brian Utter, Amy L Graves, Katharina Vollmayr-Lee Mohammad Galadari, Divya Iyer, Fernaldy Wirawan, Vanessa Huaco, Ricardo Martinez, Michael Gallagher, Laurent Pilon, Kanji Ono, Dante Simonetti, Guarav Sant, Samanvaya Srivastava
Erdong Chen - Investment Banking Analyst - Evalueserve - LinkedIn Erdong Chen - Investment Banking Analyst - Evalueserve - LinkedIn
Amin Danesh, AKM Sadman Mahmud, Michael J Bolish, Jean Luc Ishimwe, Xiang Li, Cacey S Bester, Brian Utter, Amy L Graves, Katharina Vollmayr-LeeGene set variation analysis (GSVA) revealed three distinct mEPC subtypes based on MSigDb_C6 signatures. Subtype I (metaplastic mEPCs) exhibited enrichment of KRAS-related circuits and highly expressed enterocyte-like ( REG4, OLFM4, MUC2) or gastric cell-like ( LYZ, PGC, MUC6) markers (Fig. 3c, d; Supplementary Table S7), implying intestinal and/or pseudopyloric metaplasia. Related patients (GBC1, 9, 10) generally had an earlier stage of disease and good-to-moderate differentiation associated with gallbladder polyps or PBM. Subtype II (inflammatory mEPCs) exhibited enriched inflammatory pathways (e.g., NF-κB, IL-2, IL-15) and DNA damage-related pathways (e.g., P53, RB, MYC) (Fig. 3c), reminiscent of the exacerbated tumor-promoting DNA damage induced by chronic inflammation 23. Plentiful immune or inflammatory marker genes (e.g., CXCL5, CTSD, BST2, CD47) were identified (Fig. 3d). Most related cases (GBC4, 5, 7, 8) had gallstones and suffered an advanced stage with poor differentiation and lymph node metastasis. As for subtype III (mesenchymal mEPCs; GBC2, 9, 11, 12), in addition to upregulated KRAS-related pathways, we noted activated SRC and Wnt pathways, both serving as master regulators of cell-cell adhesion and EMP 24, 25, and typical marker genes associated with cell migration (e.g., GJA1, MT1H) and EMP (e.g., SPP1, MSLN) (Fig. 3c, d). IHC analysis further validated increased protein levels of subtype-specific markers in corresponding GBC patients, including MUC2, CTSD, and MSLN for subtypes I, II, and III, respectively (Supplementary Fig. S6a–c). Based on subtype-specific single-cell transcriptomic signatures, we calculated a reference matrix for deconvolution analysis of the bulk RNA-seq data in the EGA GBC cohort ( n = 111). The decomposition analysis of this external validation cohort revealed three phenotypes akin to our classification system, with more early-stage GBCs in subtype I. In line with our findings, enriched KRAS-related signaling was present for subtypes I and III but not for subtype II, which conversely showed enriched ERBB2 and P53 pathways (Fig. 3e).
Phys. Rev. Accel. Beams 19, 103401 (2016) - Experimental
N00.00235: Structural and functional characterization of unmodified and pyroglutamylated amyloid beta peptides in lipid bilayers
Martinez, F. O. & Gordon, S. The M1 and M2 paradigm of macrophage activation: time for reassessment. F1000Prime Rep. 6, 13 (2014). N00.00268: Chemotactic behavior of a self-phoretic Janus Particle near a chemically emitting patch.
Restructuring and insolvency: PRC firms in China | Law firm Restructuring and insolvency: PRC firms in China | Law firm
Tomamichel M, Fehr S, Kaniewski J, Wehner S (2013) One-sided device-independent qkd and position-based cryptography from monogamy games. In: EUROCRYPT, pp 609–625 N00.00030: A mesoscale approach to model polyethylene degradation under a local temperature gradient N00.00334: One nose but two nostrils: interaction between two hemispheres aligns bilateral responses Roa, I. et al. Preneoplastic lesions and gallbladder cancer: an estimate of the period required for progression. Gastroenterology 111, 232–236 (1996). Zhang, L. et al. Single-cell analyses inform mechanisms of myeloid-targeted therapies in colon cancer. Cell 181, 442–459.e429 (2020).N00.00255: Thermodynamically-consistent formulation of stochastic chemistry for modeling reactive gas dynamics at small scales
Great Deal 
New Comment